| 9/4/2010 | Sam Houston 3 @ Baylor Bears 34 | |
| 9/18/2010 | Sam Houston 14 @ Western Illinois Leathernecks 56 | |
| 9/25/2010 | Gardner-Webb Runnin' Bulldogs 14 @ Sam Houston 30 | |
| 10/2/2010 | Sam Houston 38 @ Lamar Cardinals 10 | † |
| 10/9/2010 | Sam Houston 26 @ Nicholls State Colonels 7 | † |
| 10/16/2010 | Southeastern Louisiana Lions 7 @ Sam Houston 57 | † |
| 10/23/2010 | Stephen F. Austin Lumberjacks 31 vs Sam Houston 28 (Houston TX) | † |
| 10/30/2010 | Sam Houston 20 @ Northwestern State Demons 23 1OT | † |
| 11/6/2010 | McNeese State Cowboys 33 @ Sam Houston 28 | † |
| 11/13/2010 | Sam Houston 20 @ Central Arkansas Bears 13 | † |
| 11/20/2010 | Texas State Bobcats 29 @ Sam Houston 31 | † |