| 9/4/2010 | Stephen F. Austin 7 @ Texas A&M Aggies 48 | |
| 9/11/2010 | Albany NY Great Danes 14 @ Stephen F. Austin 59 | |
| 9/18/2010 | Stephen F. Austin 22 @ Northern Iowa Panthers 20 | |
| 9/25/2010 | Lamar Cardinals 3 @ Stephen F. Austin 71 | † |
| 10/9/2010 | Stephen F. Austin 32 @ McNeese State Cowboys 27 | † |
| 10/16/2010 | Central Arkansas Bears 7 @ Stephen F. Austin 30 | † |
| 10/23/2010 | Stephen F. Austin 31 vs Sam Houston Bearkats 28 (Houston TX) | † |
| 10/30/2010 | Texas State Bobcats 27 @ Stephen F. Austin 24 | † |
| 11/6/2010 | Stephen F. Austin 48 @ Nicholls State Colonels 13 | † |
| 11/13/2010 | Southeastern Louisiana Lions 14 @ Stephen F. Austin 51 | † |
| 11/20/2010 | Northwestern State Demons 13 @ Stephen F. Austin 36 | † |
| 12/4/2010 | Villanova Wildcats 54 @ Stephen F. Austin 24 |