| 9/4/2010 | Eastern Illinois Panthers 7 @ Iowa 37 | |
| 9/11/2010 | Iowa State Cyclones 7 @ Iowa 35 | |
| 9/18/2010 | Iowa 27 @ Arizona Wildcats 34 | |
| 9/25/2010 | Ball State Cardinals 0 @ Iowa 45 | |
| 10/2/2010 | Penn State Nittany Lions 3 @ Iowa 24 | † |
| 10/16/2010 | Iowa 38 @ Michigan Wolverines 28 | † |
| 10/23/2010 | Wisconsin Badgers 31 @ Iowa 30 | † |
| 10/30/2010 | Michigan State Spartans 6 @ Iowa 37 | † |
| 11/6/2010 | Iowa 18 @ Indiana Hoosiers 13 | † |
| 11/13/2010 | Iowa 17 @ Northwestern Wildcats 21 | † |
| 11/20/2010 | Ohio State Buckeyes 20 @ Iowa 17 | † |
| 11/27/2010 | Iowa 24 @ Minnesota Golden Gophers 27 | † |
| 12/28/2010 | Missouri Tigers 24 vs Iowa 27 (Phoenix - Insight Bowl) |