| 9/4/2010 | Miami-Ohio 12 @ Florida Gators 34 | |
| 9/11/2010 | Eastern Michigan Eagles 21 @ Miami-Ohio 28 | † |
| 9/18/2010 | Colorado State Rams 10 @ Miami-Ohio 31 | |
| 9/25/2010 | Miami-Ohio 13 @ Missouri Tigers 51 | |
| 10/2/2010 | Kent State Golden Flashes 21 @ Miami-Ohio 27 | † |
| 10/9/2010 | Miami-Ohio 3 @ Cincinnati Bearcats 45 | |
| 10/16/2010 | Miami-Ohio 27 @ Central Michigan Chippewas 20 | † |
| 10/23/2010 | Ohio Bobcats 34 @ Miami-Ohio 13 | † |
| 10/30/2010 | Miami-Ohio 21 @ Buffalo Bulls 9 | † |
| 11/10/2010 | Miami-Ohio 24 @ Bowling Green Falcons 21 | † |
| 11/17/2010 | Miami-Ohio 19 @ Akron Zips 14 | † |
| 11/23/2010 | Temple Owls 3 @ Miami-Ohio 23 | † |
| 12/3/2010 | Northern Illinois Huskies 21 vs Miami-Ohio 26 (MAC Championship) | † |
| 1/6/2011 | Middle Tenn State Blue Raiders 21 vs Miami-Ohio 35 (Mobile - GoDaddy.com Bowl) |