| 9/4/2010 | Illinois 13 vs Missouri Tigers 23 (St Louis MO) | |
| 9/11/2010 | Southern Illinois Salukis 3 @ Illinois 35 | |
| 9/18/2010 | Northern Illinois Huskies 22 @ Illinois 28 | |
| 10/2/2010 | Ohio State Buckeyes 24 @ Illinois 13 | † |
| 10/9/2010 | Illinois 33 @ Penn State Nittany Lions 13 | † |
| 10/16/2010 | Illinois 6 @ Michigan State Spartans 26 | † |
| 10/23/2010 | Indiana Hoosiers 13 @ Illinois 43 | † |
| 10/30/2010 | Purdue Boilermakers 10 @ Illinois 44 | † |
| 11/6/2010 | Illinois 65 @ Michigan Wolverines 67 3OT | † |
| 11/13/2010 | Minnesota Golden Gophers 38 @ Illinois 34 | † |
| 11/20/2010 | Illinois 48 @ Northwestern Wildcats 27 | † |
| 12/3/2010 | Illinois 23 @ Fresno State Bulldogs 25 | |
| 12/29/2010 | Illinois 38 vs Baylor Bears 14 (Houston - Texas Bowl) |