| 9/4/2010 | Washington 17 @ BYU Cougars 23 | |
| 9/11/2010 | Syracuse Orangemen 20 @ Washington 41 | |
| 9/18/2010 | Nebraska Cornhuskers 56 @ Washington 21 | |
| 10/2/2010 | Washington 32 @ Southern California Trojans 31 | † |
| 10/9/2010 | Arizona State Sun Devils 24 @ Washington 14 | † |
| 10/16/2010 | Oregon State Beavers 34 @ Washington 35 2OT | † |
| 10/23/2010 | Washington 14 @ Arizona Wildcats 44 | † |
| 10/30/2010 | Stanford Cardinal 41 @ Washington 0 | † |
| 11/6/2010 | Washington 16 @ Oregon Ducks 53 | † |
| 11/18/2010 | UCLA Bruins 7 @ Washington 24 | † |
| 11/27/2010 | Washington 16 @ California Golden Bears 13 | † |
| 12/4/2010 | Washington 35 @ Washington State Cougars 28 | † |
| 12/30/2010 | Nebraska Cornhuskers 7 vs Washington 19 (San Diego - Holiday Bowl) |