| 9/4/2010 | South Carolina State Bulldogs 10 @ Georgia Tech 41 | |
| 9/11/2010 | Georgia Tech 25 @ Kansas Jayhawks 28 | |
| 9/18/2010 | Georgia Tech 30 @ North Carolina Tar Heels 24 | † |
| 9/25/2010 | North Carolina State Wolfpack 45 @ Georgia Tech 28 | † |
| 10/2/2010 | Georgia Tech 24 @ Wake Forest Demon Deacons 20 | † |
| 10/9/2010 | Virginia Cavaliers 21 @ Georgia Tech 33 | † |
| 10/16/2010 | Middle Tenn State Blue Raiders 14 @ Georgia Tech 42 | |
| 10/23/2010 | Georgia Tech 13 @ Clemson Tigers 27 | † |
| 11/4/2010 | Georgia Tech 21 @ Virginia Tech Hokies 28 | † |
| 11/13/2010 | Miami-Florida Hurricanes 35 @ Georgia Tech 10 | † |
| 11/20/2010 | Duke Blue Devils 20 @ Georgia Tech 30 | † |
| 11/27/2010 | Georgia Tech 34 @ Georgia Bulldogs 42 | |
| 12/27/2010 | Air Force Falcons 14 vs Georgia Tech 7 (Shreveport - Independence Bowl) |