| 9/4/2010 | Texas Longhorns 34 @ Rice 17 | |
| 9/11/2010 | Rice 32 @ North Texas Eagles 31 | |
| 9/18/2010 | Northwestern Wildcats 30 @ Rice 13 | |
| 9/25/2010 | Baylor Bears 30 @ Rice 13 | |
| 10/2/2010 | SMU Mustangs 42 @ Rice 31 | † |
| 10/9/2010 | Rice 24 @ UTEP Miners 44 | † |
| 10/16/2010 | Houston Cougars 31 @ Rice 34 | † |
| 10/23/2010 | Rice 14 @ UCF Knights 41 | † |
| 11/6/2010 | Rice 27 @ Tulsa Golden Hurricane 64 | † |
| 11/13/2010 | Rice 49 @ Tulane Green Wave 54 | † |
| 11/20/2010 | East Carolina Pirates 38 @ Rice 62 | † |
| 11/27/2010 | UAB Blazers 23 @ Rice 28 | † |