| 9/4/2010 | Connecticut 10 @ Michigan Wolverines 30 | |
| 9/11/2010 | Texas Southern Tigers 3 @ Connecticut 62 | |
| 9/18/2010 | Connecticut 16 @ Temple Owls 30 | |
| 9/25/2010 | Buffalo Bulls 21 @ Connecticut 45 | |
| 10/2/2010 | Vanderbilt Commodores 21 @ Connecticut 40 | |
| 10/8/2010 | Connecticut 24 @ Rutgers Scarlet Knights 27 | † |
| 10/23/2010 | Connecticut 0 @ Louisville Cardinals 26 | † |
| 10/29/2010 | West Virginia Mountaineers 13 @ Connecticut 16 1OT | † |
| 11/11/2010 | Pittsburgh Panthers 28 @ Connecticut 30 | † |
| 11/20/2010 | Connecticut 23 @ Syracuse Orangemen 6 | † |
| 11/27/2010 | Cincinnati Bearcats 17 @ Connecticut 38 | † |
| 12/4/2010 | Connecticut 19 @ South Florida Bulls 16 | † |
| 1/1/2011 | Connecticut 20 vs Oklahoma Sooners 48 (Glendale - Fiesta Bowl) |