| 9/2/2010 | Rhode Island Rams 0 @ Buffalo 31 | |
| 9/11/2010 | Buffalo 6 @ Baylor Bears 34 | |
| 9/18/2010 | UCF Knights 24 @ Buffalo 10 | |
| 9/25/2010 | Buffalo 21 @ Connecticut Huskies 45 | |
| 10/2/2010 | Buffalo 28 @ Bowling Green Falcons 26 | † |
| 10/16/2010 | Buffalo 14 @ Northern Illinois Huskies 45 | † |
| 10/23/2010 | Temple Owls 42 @ Buffalo 0 | † |
| 10/30/2010 | Miami-Ohio Redhawks 21 @ Buffalo 9 | † |
| 11/4/2010 | Buffalo 17 @ Ohio Bobcats 34 | † |
| 11/12/2010 | Ball State Cardinals 20 @ Buffalo 3 | † |
| 11/20/2010 | Eastern Michigan Eagles 21 @ Buffalo 17 | † |
| 11/26/2010 | Buffalo 14 @ Akron Zips 22 | † |