| 9/2/2010 | Florida A&M Rattlers 0 @ Miami-Florida 45 | |
| 9/2/2010 | Presbyterian Blue Hose 13 @ Wake Forest 53 | |
| 9/4/2010 | Weber State Wildcats 20 @ Boston College 38 | |
| 9/4/2010 | North Texas Eagles 10 @ Clemson 35 | |
| 9/4/2010 | Elon Phoenix 27 @ Duke 41 | |
| 9/4/2010 | Samford Bulldogs 6 @ Florida State 59 | |
| 9/4/2010 | South Carolina State Bulldogs 10 @ Georgia Tech 41 | |
| 9/4/2010 | LSU Tigers 30 vs North Carolina 24 (Atlanta GA) | |
| 9/4/2010 | Western Carolina Catamounts 7 @ North Carolina State 48 | |
| 9/4/2010 | Richmond Spiders 13 @ Virginia 34 | |
| 9/6/2010 | Navy Midshipmen 14 vs Maryland 17 (Baltimore MD) | |
| 9/6/2010 | Boise State Broncos 33 vs Virginia Tech 30 (Landover MD) | |
| 9/11/2010 | Kent State Golden Flashes 13 @ Boston College 26 | |
| 9/11/2010 | North Carolina State 28 @ UCF Knights 21 | |
| 9/11/2010 | Presbyterian Blue Hose 21 @ Clemson 58 | |
| 9/11/2010 | Georgia Tech 25 @ Kansas Jayhawks 28 | |
| 9/11/2010 | Morgan State Golden Bears 3 @ Maryland 62 | |
| 9/11/2010 | Miami-Florida 24 @ Ohio State Buckeyes 36 | |
| 9/11/2010 | Florida State 17 @ Oklahoma Sooners 47 | |
| 9/11/2010 | Virginia 7 @ Southern California Trojans 17 | |
| 9/11/2010 | James Madison Dukes 21 @ Virginia Tech 16 | |
| 9/11/2010 | Duke 48 @ Wake Forest 54 | † |
| 9/16/2010 | Cincinnati Bearcats 19 @ North Carolina State 30 | |
| 9/18/2010 | Clemson 24 @ Auburn Tigers 27 1OT | |
| 9/18/2010 | Alabama Crimson Tide 62 @ Duke 13 | |
| 9/18/2010 | BYU Cougars 10 @ Florida State 34 | |
| 9/18/2010 | Georgia Tech 30 @ North Carolina 24 | † |
| 9/18/2010 | Wake Forest 24 @ Stanford Cardinal 68 | |
| 9/18/2010 | East Carolina Pirates 27 @ Virginia Tech 49 | |
| 9/18/2010 | Maryland 17 @ West Virginia Mountaineers 31 | |
| 9/23/2010 | Miami-Florida 31 @ Pittsburgh Panthers 3 | |
| 9/25/2010 | Virginia Tech 19 @ Boston College 0 | † |
| 9/25/2010 | Army Black Knights 35 @ Duke 21 | |
| 9/25/2010 | Wake Forest 0 @ Florida State 31 | † |
| 9/25/2010 | North Carolina State 45 @ Georgia Tech 28 | † |
| 9/25/2010 | Florida Intl Golden Panthers 28 @ Maryland 42 | |
| 9/25/2010 | North Carolina 17 @ Rutgers Scarlet Knights 13 | |
| 9/25/2010 | VMI Keydets 7 @ Virginia 48 | |
| 10/2/2010 | Notre Dame Fighting Irish 31 @ Boston College 13 | |
| 10/2/2010 | Miami-Florida 30 @ Clemson 21 | † |
| 10/2/2010 | Duke 16 @ Maryland 21 | † |
| 10/2/2010 | East Carolina Pirates 17 @ North Carolina 42 | |
| 10/2/2010 | Virginia Tech 41 @ North Carolina State 30 | † |
| 10/2/2010 | Florida State 34 @ Virginia 14 | † |
| 10/2/2010 | Georgia Tech 24 @ Wake Forest 20 | † |
| 10/9/2010 | Virginia 21 @ Georgia Tech 33 | † |
| 10/9/2010 | Florida State 45 @ Miami-Florida 17 | † |
| 10/9/2010 | Clemson 16 @ North Carolina 21 | † |
| 10/9/2010 | Boston College 17 @ North Carolina State 44 | † |
| 10/9/2010 | Central Michigan Chippewas 21 @ Virginia Tech 45 | |
| 10/9/2010 | Navy Midshipmen 28 @ Wake Forest 27 | |
| 10/16/2010 | Maryland 7 @ Clemson 31 | † |
| 10/16/2010 | Miami-Florida 28 @ Duke 13 | † |
| 10/16/2010 | North Carolina State 27 @ East Carolina Pirates 33 1OT | |
| 10/16/2010 | Boston College 19 @ Florida State 24 | † |
| 10/16/2010 | Middle Tenn State Blue Raiders 14 @ Georgia Tech 42 | |
| 10/16/2010 | North Carolina 44 @ Virginia 10 | † |
| 10/16/2010 | Wake Forest 21 @ Virginia Tech 52 | † |
| 10/23/2010 | Maryland 24 @ Boston College 21 | † |
| 10/23/2010 | Georgia Tech 13 @ Clemson 27 | † |
| 10/23/2010 | North Carolina 10 @ Miami-Florida 33 | † |
| 10/23/2010 | Eastern Michigan Eagles 21 @ Virginia 48 | |
| 10/23/2010 | Duke 7 @ Virginia Tech 44 | † |
| 10/28/2010 | Florida State 24 @ North Carolina State 28 | † |
| 10/30/2010 | Clemson 10 @ Boston College 16 | † |
| 10/30/2010 | Wake Forest 14 @ Maryland 62 | † |
| 10/30/2010 | Duke 34 @ Navy Midshipmen 31 | |
| 10/30/2010 | William & Mary Tribe 17 @ North Carolina 21 | |
| 10/30/2010 | Miami-Florida 19 @ Virginia 24 | † |
| 11/4/2010 | Georgia Tech 21 @ Virginia Tech 28 | † |
| 11/6/2010 | North Carolina State 13 @ Clemson 14 | † |
| 11/6/2010 | Virginia 48 @ Duke 56 | † |
| 11/6/2010 | North Carolina 37 @ Florida State 35 | † |
| 11/6/2010 | Maryland 20 @ Miami-Florida 26 | † |
| 11/6/2010 | Boston College 23 @ Wake Forest 13 | † |
| 11/13/2010 | Boston College 21 @ Duke 16 | † |
| 11/13/2010 | Clemson 13 @ Florida State 16 | † |
| 11/13/2010 | Miami-Florida 35 @ Georgia Tech 10 | † |
| 11/13/2010 | Virginia Tech 26 @ North Carolina 10 | † |
| 11/13/2010 | Wake Forest 3 @ North Carolina State 38 | † |
| 11/13/2010 | Maryland 42 @ Virginia 23 | † |
| 11/20/2010 | Virginia 13 @ Boston College 17 | † |
| 11/20/2010 | Duke 20 @ Georgia Tech 30 | † |
| 11/20/2010 | Florida State 30 @ Maryland 16 | † |
| 11/20/2010 | Virginia Tech 31 @ Miami-Florida 17 | † |
| 11/20/2010 | North Carolina State 29 @ North Carolina 25 | † |
| 11/20/2010 | Clemson 30 @ Wake Forest 10 | † |
| 11/27/2010 | South Carolina Gamecocks 29 @ Clemson 7 | |
| 11/27/2010 | North Carolina 24 @ Duke 19 | † |
| 11/27/2010 | Florida Gators 7 @ Florida State 31 | |
| 11/27/2010 | Georgia Tech 34 @ Georgia Bulldogs 42 | |
| 11/27/2010 | North Carolina State 31 @ Maryland 38 | † |
| 11/27/2010 | South Florida Bulls 23 @ Miami-Florida 20 1OT | |
| 11/27/2010 | Boston College 16 @ Syracuse Orangemen 7 | |
| 11/27/2010 | Wake Forest 34 @ Vanderbilt Commodores 13 | |
| 11/27/2010 | Virginia 7 @ Virginia Tech 37 | † |
| 12/4/2010 | Florida State 33 vs Virginia Tech 44 (Charlotte NC-ACC Championship) | † |
| 12/27/2010 | Air Force Falcons 14 vs Georgia Tech 7 (Shreveport - Independence Bowl) | |
| 12/28/2010 | West Virginia Mountaineers 7 vs North Carolina State 23 (Orlando - Champs Sports Bowl) | |
| 12/29/2010 | East Carolina Pirates 20 vs Maryland 51 (Washington DC - Military Bowl) | |
| 12/30/2010 | North Carolina 30 vs Tennessee Volunteers 27 (Nashville - Music City Bowl) | |
| 12/31/2010 | South Florida Bulls 31 vs Clemson 26 (Charlotte - Meineke Bowl) | |
| 12/31/2010 | South Carolina Gamecocks 17 vs Florida State 26 (Atlanta - Chik Fil-A Bowl) | |
| 12/31/2010 | Notre Dame Fighting Irish 33 vs Miami-Florida 17 (El Paso - Sun Bowl) | |
| 1/3/2011 | Stanford Cardinal 40 vs Virginia Tech 12 (Miami - Orange Bowl) | |
| 1/9/2011 | Nevada Wolf Pack 20 vs Boston College 13 (San Francisco - Kraft Fight Hunger Bowl) |