| 9/2/2010 | Presbyterian 13 @ Wake Forest Demon Deacons 53 | |
| 9/11/2010 | Presbyterian 21 @ Clemson Tigers 58 | |
| 9/18/2010 | Presbyterian 14 @ The Citadel Bulldogs 26 | |
| 9/25/2010 | North Greenville Crusaders 34 @ Presbyterian 17 | |
| 10/2/2010 | Presbyterian 13 @ VMI Keydets 24 | † |
| 10/16/2010 | Coastal Carolina Chanticleers 35 @ Presbyterian 7 | † |
| 10/23/2010 | Presbyterian 26 @ Gardner-Webb Runnin' Bulldogs 24 | † |
| 10/30/2010 | Liberty Flames 34 @ Presbyterian 24 | † |
| 11/6/2010 | Stony Brook Seawolves 37 @ Presbyterian 7 | † |
| 11/13/2010 | Presbyterian 39 @ Charleston Southern Buccaneers 42 | † |
| 11/20/2010 | Davidson Wildcats 6 @ Presbyterian 42 |