| 9/4/2010 | Western Carolina 7 @ North Carolina State Wolfpack 48 | |
| 9/11/2010 | Tusculum Pioneers 54 @ Western Carolina 30 | |
| 9/18/2010 | Western Carolina 28 @ Gardner-Webb Runnin' Bulldogs 14 | |
| 9/25/2010 | Chattanooga Moccasins 27 @ Western Carolina 21 | † |
| 10/2/2010 | Western Carolina 24 @ The Citadel Bulldogs 13 | † |
| 10/9/2010 | Samford Bulldogs 38 @ Western Carolina 7 | † |
| 10/16/2010 | Western Carolina 14 @ Wofford Terriers 45 | † |
| 10/23/2010 | Appalachian State Mountaineers 37 @ Western Carolina 14 | † |
| 11/6/2010 | Western Carolina 17 @ Furman Paladins 31 | † |
| 11/13/2010 | Georgia Southern Eagles 28 @ Western Carolina 6 | † |
| 11/20/2010 | Western Carolina 14 @ Elon Phoenix 45 | † |