| 9/2/2010 | Hampton Pirates 0 @ Central Michigan 33 | |
| 9/9/2010 | Central Michigan 10 @ Temple Owls 13 1OT | † |
| 9/18/2010 | Central Michigan 52 @ Eastern Michigan Eagles 14 | † |
| 9/25/2010 | Central Michigan 25 @ Northwestern Wildcats 30 | |
| 10/2/2010 | Ball State Cardinals 31 @ Central Michigan 17 | † |
| 10/9/2010 | Central Michigan 21 @ Virginia Tech Hokies 45 | |
| 10/16/2010 | Miami-Ohio Redhawks 27 @ Central Michigan 20 | † |
| 10/23/2010 | Central Michigan 7 @ Northern Illinois Huskies 33 | † |
| 10/30/2010 | Bowling Green Falcons 17 @ Central Michigan 14 | † |
| 11/5/2010 | Western Michigan Broncos 22 @ Central Michigan 26 | † |
| 11/13/2010 | Central Michigan 37 @ Navy Midshipmen 38 | |
| 11/26/2010 | Central Michigan 31 @ Toledo Rockets 42 | † |