| 9/2/2010 | Florida A&M 0 @ Miami-Florida Hurricanes 45 | |
| 9/11/2010 | Florida A&M 17 @ Delaware State Hornets 14 | † |
| 9/18/2010 | Florida A&M 50 @ Howard Bison 7 | † |
| 9/25/2010 | Florida A&M 18 vs Tennessee State Tigers 29 (Atlanta GA) | |
| 10/2/2010 | South Carolina State Bulldogs 19 @ Florida A&M 0 | † |
| 10/16/2010 | Savannah State Tigers 0 @ Florida A&M 31 | |
| 10/23/2010 | Florida A&M 17 @ Norfolk State Spartans 13 | † |
| 10/30/2010 | Morgan State Golden Bears 17 @ Florida A&M 31 | † |
| 11/6/2010 | Florida A&M 22 @ North Carolina A&T Aggies 19 1OT | † |
| 11/13/2010 | Hampton Pirates 12 @ Florida A&M 17 | † |
| 11/20/2010 | Florida A&M 38 vs Bethune-Cookman Wildcats 27 (Orlando FL) | † |