| 9/4/2010 | Elon 27 @ Duke Blue Devils 41 | |
| 9/11/2010 | Shaw Bears 26 @ Elon 55 | |
| 9/18/2010 | Elon 21 @ Richmond Spiders 27 1OT | |
| 9/25/2010 | Elon 21 @ Georgia Southern Eagles 38 | † |
| 10/2/2010 | Samford Bulldogs 19 @ Elon 24 | † |
| 10/9/2010 | Elon 31 @ Appalachian State Mountaineers 34 | † |
| 10/23/2010 | Wofford Terriers 28 @ Elon 21 | † |
| 10/30/2010 | Elon 49 @ Chattanooga Moccasins 35 | † |
| 11/6/2010 | Elon 27 @ The Citadel Bulldogs 16 | † |
| 11/13/2010 | Furman Paladins 25 @ Elon 30 | † |
| 11/20/2010 | Western Carolina Catamounts 14 @ Elon 45 | † |