| 9/4/2010 | South Carolina State 10 @ Georgia Tech Yellow Jackets 41 | |
| 9/11/2010 | Mississippi Valley State Delta Devils 0 @ South Carolina State 44 | |
| 9/18/2010 | South Carolina State 61 @ Benedict Tigers 20 | |
| 10/2/2010 | South Carolina State 19 @ Florida A&M Rattlers 0 | † |
| 10/9/2010 | Norfolk State Spartans 13 @ South Carolina State 34 | † |
| 10/16/2010 | Bethune-Cookman Wildcats 14 @ South Carolina State 0 | † |
| 10/23/2010 | Hampton Pirates 7 @ South Carolina State 10 | † |
| 10/30/2010 | South Carolina State 38 @ Delaware State Hornets 21 | † |
| 11/6/2010 | Howard Bison 14 @ South Carolina State 54 | † |
| 11/11/2010 | South Carolina State 32 @ Morgan State Golden Bears 10 | † |
| 11/20/2010 | South Carolina State 48 @ North Carolina A&T Aggies 3 | † |
| 11/27/2010 | South Carolina State 16 @ Georgia Southern Eagles 41 (FBS Playoffs) |