| 9/2/2010 | Marshall Thundering Herd 7 @ Ohio State 45 | |
| 9/11/2010 | Miami-Florida Hurricanes 24 @ Ohio State 36 | |
| 9/18/2010 | Ohio Bobcats 7 @ Ohio State 43 | |
| 9/25/2010 | Eastern Michigan Eagles 20 @ Ohio State 73 | |
| 10/2/2010 | Ohio State 24 @ Illinois Fighting Illini 13 | † |
| 10/9/2010 | Indiana Hoosiers 10 @ Ohio State 38 | † |
| 10/16/2010 | Ohio State 18 @ Wisconsin Badgers 31 | † |
| 10/23/2010 | Purdue Boilermakers 0 @ Ohio State 49 | † |
| 10/30/2010 | Ohio State 52 @ Minnesota Golden Gophers 10 | † |
| 11/13/2010 | Penn State Nittany Lions 14 @ Ohio State 38 | † |
| 11/20/2010 | Ohio State 20 @ Iowa Hawkeyes 17 | † |
| 11/27/2010 | Michigan Wolverines 7 @ Ohio State 37 | † |
| 1/4/2011 | Ohio State 31 vs Arkansas Razorbacks 26 (New Orleans - Sugar Bowl) |