| 9/4/2010 | Purdue Boilermakers 12 @ Notre Dame 23 |
| 9/11/2010 | Michigan Wolverines 28 @ Notre Dame 24 |
| 9/18/2010 | Notre Dame 31 @ Michigan State Spartans 34 1OT |
| 9/25/2010 | Stanford Cardinal 37 @ Notre Dame 14 |
| 10/2/2010 | Notre Dame 31 @ Boston College Eagles 13 |
| 10/9/2010 | Pittsburgh Panthers 17 @ Notre Dame 23 |
| 10/16/2010 | Western Michigan Broncos 20 @ Notre Dame 44 |
| 10/23/2010 | Notre Dame 17 vs Navy Midshipmen 35 (East Rutherford NJ) |
| 10/30/2010 | Tulsa Golden Hurricane 28 @ Notre Dame 27 |
| 11/13/2010 | Utah Utes 3 @ Notre Dame 28 |
| 11/20/2010 | Notre Dame 27 vs Army Black Knights 3 (Bronx NY) |
| 11/27/2010 | Notre Dame 20 @ Southern California Trojans 16 |
| 12/31/2010 | Notre Dame 33 vs Miami-Florida Hurricanes 17 (El Paso - Sun Bowl) |