| 9/2/2010 | Southern Miss Golden Eagles 13 @ South Carolina 41 | |
| 9/11/2010 | Georgia Bulldogs 6 @ South Carolina 17 | † |
| 9/18/2010 | Furman Paladins 19 @ South Carolina 38 | |
| 9/25/2010 | South Carolina 27 @ Auburn Tigers 35 | † |
| 10/9/2010 | Alabama Crimson Tide 21 @ South Carolina 35 | † |
| 10/16/2010 | South Carolina 28 @ Kentucky Wildcats 31 | † |
| 10/23/2010 | South Carolina 21 @ Vanderbilt Commodores 7 | † |
| 10/30/2010 | Tennessee Volunteers 24 @ South Carolina 38 | † |
| 11/6/2010 | Arkansas Razorbacks 41 @ South Carolina 20 | † |
| 11/13/2010 | South Carolina 36 @ Florida Gators 14 | † |
| 11/20/2010 | Troy Trojans 24 @ South Carolina 69 | |
| 11/27/2010 | South Carolina 29 @ Clemson Tigers 7 | |
| 12/4/2010 | Auburn Tigers 56 vs South Carolina 17 (Atlanta GA - SEC Championship) | † |
| 12/31/2010 | South Carolina 17 vs Florida State Seminoles 26 (Atlanta - Chik Fil-A Bowl) |