| 9/4/2010 | Utah State Aggies 24 @ Oklahoma 31 | |
| 9/11/2010 | Florida State Seminoles 17 @ Oklahoma 47 | |
| 9/18/2010 | Air Force Falcons 24 @ Oklahoma 27 | |
| 9/25/2010 | Oklahoma 31 @ Cincinnati Bearcats 29 | |
| 10/2/2010 | Oklahoma 28 vs Texas Longhorns 20 (Dallas TX) | † |
| 10/16/2010 | Iowa State Cyclones 0 @ Oklahoma 52 | † |
| 10/23/2010 | Oklahoma 27 @ Missouri Tigers 36 | † |
| 10/30/2010 | Colorado Buffaloes 10 @ Oklahoma 43 | † |
| 11/6/2010 | Oklahoma 19 @ Texas A&M Aggies 33 | † |
| 11/13/2010 | Texas Tech Red Raiders 7 @ Oklahoma 45 | † |
| 11/20/2010 | Oklahoma 53 @ Baylor Bears 24 | † |
| 11/27/2010 | Oklahoma 47 @ Oklahoma State Cowboys 41 | † |
| 12/4/2010 | Nebraska Cornhuskers 20 vs Oklahoma 23 (Arlington TX-Big 12 Championship ) | † |
| 1/1/2011 | Connecticut Huskies 20 vs Oklahoma 48 (Glendale - Fiesta Bowl) |