| 9/2/2010 | Minnesota Golden Gophers 24 @ Middle Tenn State 17 | |
| 9/11/2010 | Austin Peay Governers 33 @ Middle Tenn State 56 | |
| 9/18/2010 | Middle Tenn State 17 @ Memphis Tigers 24 | |
| 9/25/2010 | Middle Tenn State 34 @ UL Lafayette Ragin' Cajuns 14 | † |
| 10/5/2010 | Troy Trojans 42 @ Middle Tenn State 13 | † |
| 10/16/2010 | Middle Tenn State 14 @ Georgia Tech Yellow Jackets 42 | |
| 10/23/2010 | UL Monroe Warhawks 10 @ Middle Tenn State 38 | † |
| 11/2/2010 | Middle Tenn State 24 @ Arkansas State Red Wolves 51 | † |
| 11/13/2010 | North Texas Eagles 23 @ Middle Tenn State 17 | † |
| 11/20/2010 | Middle Tenn State 27 @ Western Kentucky Hilltoppers 26 | † |
| 11/27/2010 | Florida Atlantic Owls 14 @ Middle Tenn State 38 | † |
| 12/4/2010 | Middle Tenn State 28 @ Florida Intl Golden Panthers 27 | † |
| 1/6/2011 | Middle Tenn State 21 vs Miami-Ohio Redhawks 35 (Mobile - GoDaddy.com Bowl) |