| 9/4/2010 | Lock Haven Bald Eagles 6 @ VMI 48 | |
| 9/11/2010 | VMI 0 @ William & Mary Tribe 45 | |
| 9/25/2010 | VMI 7 @ Virginia Cavaliers 48 | |
| 10/2/2010 | Presbyterian Blue Hose 13 @ VMI 24 | † |
| 10/9/2010 | VMI 9 @ Stony Brook Seawolves 27 | † |
| 10/16/2010 | Liberty Flames 41 @ VMI 7 | † |
| 10/23/2010 | VMI 34 @ Charleston Southern Buccaneers 16 | † |
| 10/30/2010 | VMI 7 @ Army Black Knights 29 | |
| 11/6/2010 | Coastal Carolina Chanticleers 31 @ VMI 3 | † |
| 11/13/2010 | VMI 28 @ Old Dominion Monarchs 45 | |
| 11/20/2010 | VMI 7 @ Gardner-Webb Runnin' Bulldogs 10 | † |