| 9/4/2010 | William & Mary 23 @ Massachusetts Minutemen 27 | † |
| 9/11/2010 | VMI Keydets 0 @ William & Mary 45 | |
| 9/18/2010 | William & Mary 21 @ Old Dominion Monarchs 17 | |
| 9/25/2010 | William & Mary 24 @ Maine Black Bears 21 | † |
| 10/2/2010 | Villanova Wildcats 24 @ William & Mary 31 | † |
| 10/9/2010 | Rhode Island Rams 7 @ William & Mary 26 | † |
| 10/23/2010 | Delaware Blue Hens 16 @ William & Mary 17 | † |
| 10/30/2010 | William & Mary 17 @ North Carolina Tar Heels 21 | |
| 11/6/2010 | William & Mary 13 @ New Hampshire Wildcats 3 | † |
| 11/13/2010 | William & Mary 24 @ James Madison Dukes 30 | † |
| 11/20/2010 | Richmond Spiders 3 @ William & Mary 41 | † |
| 12/4/2010 | Georgia Southern Eagles 31 @ William & Mary 15 |