| 9/4/2010 | Samford 6 @ Florida State Seminoles 59 | |
| 9/11/2010 | Samford 19 @ Northwestern State Demons 7 | |
| 9/16/2010 | Newberry Wolves 35 @ Samford 38 | |
| 9/25/2010 | Appalachian State Mountaineers 35 @ Samford 17 | † |
| 10/2/2010 | Samford 19 @ Elon Phoenix 24 | † |
| 10/9/2010 | Samford 38 @ Western Carolina Catamounts 7 | † |
| 10/16/2010 | Furman Paladins 27 @ Samford 10 | † |
| 10/30/2010 | Samford 20 @ Georgia Southern Eagles 13 | † |
| 11/6/2010 | Wofford Terriers 10 @ Samford 3 | † |
| 11/13/2010 | Samford 14 @ Chattanooga Moccasins 48 | † |
| 11/20/2010 | The Citadel Bulldogs 13 @ Samford 12 | † |