| 9/4/2010 | Army Black Knights 31 @ Eastern Michigan 27 | |
| 9/11/2010 | Eastern Michigan 21 @ Miami-Ohio Redhawks 28 | † |
| 9/18/2010 | Central Michigan Chippewas 52 @ Eastern Michigan 14 | † |
| 9/25/2010 | Eastern Michigan 20 @ Ohio State Buckeyes 73 | |
| 10/2/2010 | Ohio Bobcats 30 @ Eastern Michigan 17 | † |
| 10/9/2010 | Eastern Michigan 6 @ Vanderbilt Commodores 52 | |
| 10/16/2010 | Eastern Michigan 41 @ Ball State Cardinals 38 1OT | † |
| 10/23/2010 | Eastern Michigan 21 @ Virginia Cavaliers 48 | |
| 10/30/2010 | Toledo Rockets 42 @ Eastern Michigan 7 | † |
| 11/13/2010 | Eastern Michigan 30 @ Western Michigan Broncos 45 | † |
| 11/20/2010 | Eastern Michigan 21 @ Buffalo Bulls 17 | † |
| 11/26/2010 | Northern Illinois Huskies 71 @ Eastern Michigan 3 | † |