| 9/4/2010 | North Dakota State Bison 6 @ Kansas 3 | |
| 9/11/2010 | Georgia Tech Yellow Jackets 25 @ Kansas 28 | |
| 9/17/2010 | Kansas 16 @ Southern Miss Golden Eagles 31 | |
| 9/25/2010 | New Mexico State Aggies 16 @ Kansas 42 | |
| 10/2/2010 | Kansas 7 @ Baylor Bears 55 | † |
| 10/14/2010 | Kansas State Wildcats 59 @ Kansas 7 | † |
| 10/23/2010 | Texas A&M Aggies 45 @ Kansas 10 | † |
| 10/30/2010 | Kansas 16 @ Iowa State Cyclones 28 | † |
| 11/6/2010 | Colorado Buffaloes 45 @ Kansas 52 | † |
| 11/13/2010 | Kansas 3 @ Nebraska Cornhuskers 20 | † |
| 11/20/2010 | Oklahoma State Cowboys 48 @ Kansas 14 | † |
| 11/27/2010 | Missouri Tigers 35 vs Kansas 7 (Kansas City MO) | † |