| 9/2/2010 | Southern California 49 @ Hawaii Warriors 36 | |
| 9/11/2010 | Virginia Cavaliers 7 @ Southern California 17 | |
| 9/18/2010 | Southern California 32 @ Minnesota Golden Gophers 21 | |
| 9/25/2010 | Southern California 50 @ Washington State Cougars 16 | † |
| 10/2/2010 | Washington Huskies 32 @ Southern California 31 | † |
| 10/9/2010 | Southern California 35 @ Stanford Cardinal 37 | † |
| 10/16/2010 | California Golden Bears 14 @ Southern California 48 | † |
| 10/30/2010 | Oregon Ducks 53 @ Southern California 32 | † |
| 11/6/2010 | Arizona State Sun Devils 33 @ Southern California 34 | † |
| 11/13/2010 | Southern California 24 @ Arizona Wildcats 21 | † |
| 11/20/2010 | Southern California 7 @ Oregon State Beavers 36 | † |
| 11/27/2010 | Notre Dame Fighting Irish 20 @ Southern California 16 | |
| 12/4/2010 | Southern California 28 @ UCLA Bruins 14 | † |