| 9/4/2010 | Coastal Carolina Chanticleers 0 @ West Virginia 31 | |
| 9/10/2010 | West Virginia 24 @ Marshall Thundering Herd 21 1OT | |
| 9/18/2010 | Maryland Terrapins 17 @ West Virginia 31 | |
| 9/25/2010 | West Virginia 14 @ LSU Tigers 20 | |
| 10/9/2010 | UNLV Rebels 10 @ West Virginia 49 | |
| 10/14/2010 | South Florida Bulls 6 @ West Virginia 20 | † |
| 10/23/2010 | Syracuse Orangemen 19 @ West Virginia 14 | † |
| 10/29/2010 | West Virginia 13 @ Connecticut Huskies 16 1OT | † |
| 11/13/2010 | Cincinnati Bearcats 10 @ West Virginia 37 | † |
| 11/20/2010 | West Virginia 17 @ Louisville Cardinals 10 | † |
| 11/26/2010 | West Virginia 35 @ Pittsburgh Panthers 10 | † |
| 12/4/2010 | Rutgers Scarlet Knights 14 @ West Virginia 35 | † |
| 12/28/2010 | West Virginia 7 vs North Carolina State Wolfpack 23 (Orlando - Champs Sports Bowl) |