| 9/4/2010 | Tennessee-Martin Skyhawks 0 @ Tennessee 50 | |
| 9/11/2010 | Oregon Ducks 48 @ Tennessee 13 | |
| 9/18/2010 | Florida Gators 31 @ Tennessee 17 | † |
| 9/25/2010 | UAB Blazers 29 @ Tennessee 32 2OT | |
| 10/2/2010 | Tennessee 14 @ LSU Tigers 16 | † |
| 10/9/2010 | Tennessee 14 @ Georgia Bulldogs 41 | † |
| 10/23/2010 | Alabama Crimson Tide 41 @ Tennessee 10 | † |
| 10/30/2010 | Tennessee 24 @ South Carolina Gamecocks 38 | † |
| 11/6/2010 | Tennessee 50 @ Memphis Tigers 14 | |
| 11/13/2010 | Mississippi Rebels 14 @ Tennessee 52 | † |
| 11/20/2010 | Tennessee 24 @ Vanderbilt Commodores 10 | † |
| 11/27/2010 | Kentucky Wildcats 14 @ Tennessee 24 | † |
| 12/30/2010 | North Carolina Tar Heels 30 vs Tennessee 27 (Nashville - Music City Bowl) |