| 9/4/2010 | Northwestern Wildcats 23 @ Vanderbilt 21 | |
| 9/11/2010 | LSU Tigers 27 @ Vanderbilt 3 | † |
| 9/18/2010 | Vanderbilt 28 @ Mississippi Rebels 14 | † |
| 10/2/2010 | Vanderbilt 21 @ Connecticut Huskies 40 | |
| 10/9/2010 | Eastern Michigan Eagles 6 @ Vanderbilt 52 | |
| 10/16/2010 | Vanderbilt 0 @ Georgia Bulldogs 43 | † |
| 10/23/2010 | South Carolina Gamecocks 21 @ Vanderbilt 7 | † |
| 10/30/2010 | Vanderbilt 14 @ Arkansas Razorbacks 49 | † |
| 11/6/2010 | Florida Gators 55 @ Vanderbilt 14 | † |
| 11/13/2010 | Vanderbilt 20 @ Kentucky Wildcats 38 | † |
| 11/20/2010 | Tennessee Volunteers 24 @ Vanderbilt 10 | † |
| 11/27/2010 | Wake Forest Demon Deacons 34 @ Vanderbilt 13 |