| 8/27/2022 | Wyoming | 6 | at | Illinois | 38 | MW | ||
| Nebraska | 28 | vs | Northwestern | 31 | Dublin IE | |||
| 9/1/2022 | New Mexico State | 0 | at | Minnesota | 38 | Ind | ||
| Penn State | 35 | at | Purdue | 31 | ||||
| 9/2/2022 | Illinois | 20 | at | Indiana | 23 | |||
| Western Michigan | 13 | at | Michigan State | 35 | MAC | |||
| 9/3/2022 | Rutgers | 22 | at | Boston College | 21 | @ ACC | ||
| South Dakota State | 3 | at | Iowa | 7 | MVC (1AA) | |||
| Buffalo | 10 | at | Maryland | 31 | MAC | |||
| Colorado State | 7 | at | Michigan | 51 | MW | |||
| North Dakota | 17 | at | Nebraska | 38 | MVC (1AA) | |||
| Notre Dame | 10 | at | Ohio State | 21 | ND | |||
| Illinois State | 0 | at | Wisconsin | 38 | MVC (1AA) | |||
| 9/10/2022 | Virginia | 3 | at | Illinois | 24 | ACC | ||
| Idaho | 22 | at | Indiana | 35 | BSky (1AA) | |||
| Iowa State | 10 | at | Iowa | 7 | B12 | |||
| Hawaii | 10 | at | Michigan | 56 | MW | |||
| Akron | 0 | at | Michigan State | 52 | MAC | |||
| Western Illinois | 10 | at | Minnesota | 62 | MVC (1AA) | |||
| Georgia Southern | 45 | at | Nebraska | 42 | SBC | |||
| Duke | 31 | at | Northwestern | 23 | ACC | |||
| Arkansas State | 12 | at | Ohio State | 45 | SBC | |||
| Ohio | 10 | at | Penn State | 46 | MAC | |||
| Indiana State | 0 | at | Purdue | 56 | MVC (1AA) | |||
| Wagner | 7 | at | Rutgers | 66 | NE (1AA) | |||
| Maryland | 56 | at | UNC-Charlotte | 21 | @ CUSA | |||
| Washington State | 17 | at | Wisconsin | 14 | P12 | |||
| 9/17/2022 | Penn State | 41 | at | Auburn | 12 | @ SEC | ||
| Western Kentucky | 30 | at | Indiana | 33 | CUSA | |||
| Nevada | 0 | at | Iowa | 27 | MW | |||
| SMU | 27 | at | Maryland | 34 | AAC | |||
| Connecticut | 0 | at | Michigan | 59 | Ind | |||
| Colorado | 7 | at | Minnesota | 49 | P12 | |||
| Oklahoma | 49 | at | Nebraska | 14 | B12 | |||
| Southern Illinois | 31 | at | Northwestern | 24 | MVC (1AA) | |||
| Toledo | 21 | at | Ohio State | 77 | MAC | |||
| Purdue | 29 | at | Syracuse | 32 | @ ACC | |||
| Rutgers | 16 | at | Temple | 14 | @ AAC | |||
| Michigan State | 28 | at | Washington | 39 | @ P12 | |||
| New Mexico State | 7 | at | Wisconsin | 66 | Ind | |||
| 9/22/2022 | Chattanooga | 0 | at | Illinois | 31 | SoCon (1AA) | ||
| 9/24/2022 | Indiana | 24 | at | Cincinnati | 45 | @ AAC | ||
| Maryland | 27 | at | Michigan | 34 | ||||
| Minnesota | 34 | at | Michigan State | 7 | ||||
| Miami-Ohio | 17 | at | Northwestern | 14 | MAC | |||
| Wisconsin | 21 | at | Ohio State | 52 | ||||
| Central Michigan | 14 | at | Penn State | 33 | MAC | |||
| Florida Atlantic | 26 | at | Purdue | 28 | CUSA | |||
| Iowa | 27 | at | Rutgers | 10 | ||||
| 10/1/2022 | Michigan | 27 | at | Iowa | 14 | |||
| Michigan State | 13 | at | Maryland | 27 | ||||
| Purdue | 20 | at | Minnesota | 10 | ||||
| Indiana | 21 | at | Nebraska | 35 | ||||
| Rutgers | 10 | at | Ohio State | 49 | ||||
| Northwestern | 7 | at | Penn State | 17 | ||||
| Illinois | 34 | at | Wisconsin | 10 | ||||
| 10/7/2022 | Nebraska | 14 | at | Rutgers | 13 | |||
| 10/8/2022 | Iowa | 6 | at | Illinois | 9 | |||
| Michigan | 31 | at | Indiana | 10 | ||||
| Purdue | 31 | at | Maryland | 29 | ||||
| Ohio State | 49 | at | Michigan State | 20 | ||||
| Wisconsin | 42 | at | Northwestern | 7 | ||||
| 10/15/2022 | Minnesota | 14 | at | Illinois | 26 | |||
| Maryland | 38 | at | Indiana | 33 | ||||
| Penn State | 17 | at | Michigan | 41 | ||||
| Wisconsin | 28 | at | Michigan State | 34 | 2OT | |||
| Nebraska | 37 | at | Purdue | 43 | ||||
| 10/22/2022 | Northwestern | 24 | at | Maryland | 31 | |||
| Iowa | 10 | at | Ohio State | 54 | ||||
| Minnesota | 17 | at | Penn State | 45 | ||||
| Indiana | 17 | at | Rutgers | 24 | ||||
| Purdue | 24 | at | Wisconsin | 35 | ||||
| 10/29/2022 | Northwestern | 13 | at | Iowa | 33 | |||
| Michigan State | 7 | at | Michigan | 29 | ||||
| Rutgers | 0 | at | Minnesota | 31 | ||||
| Illinois | 26 | at | Nebraska | 9 | ||||
| Ohio State | 44 | at | Penn State | 31 | ||||
| 11/5/2022 | Michigan State | 23 | at | Illinois | 15 | |||
| Penn State | 45 | at | Indiana | 14 | ||||
| Minnesota | 20 | at | Nebraska | 13 | ||||
| Ohio State | 21 | at | Northwestern | 7 | ||||
| Iowa | 24 | at | Purdue | 3 | ||||
| Michigan | 52 | at | Rutgers | 17 | ||||
| Maryland | 10 | at | Wisconsin | 23 | ||||
| 11/12/2022 | Purdue | 31 | at | Illinois | 24 | |||
| Wisconsin | 10 | at | Iowa | 24 | ||||
| Nebraska | 3 | at | Michigan | 34 | ||||
| Rutgers | 21 | at | Michigan State | 27 | ||||
| Northwestern | 3 | at | Minnesota | 31 | ||||
| Indiana | 14 | at | Ohio State | 56 | ||||
| Maryland | 0 | at | Penn State | 30 | ||||
| 11/19/2022 | Ohio State | 43 | at | Maryland | 30 | |||
| Illinois | 17 | at | Michigan | 19 | ||||
| Indiana | 39 | at | Michigan State | 31 | 2OT | |||
| Iowa | 13 | at | Minnesota | 10 | ||||
| Wisconsin | 15 | at | Nebraska | 14 | ||||
| Northwestern | 9 | at | Purdue | 17 | ||||
| Penn State | 55 | at | Rutgers | 10 | ||||
| 11/25/2022 | Nebraska | 24 | at | Iowa | 17 | |||
| 11/26/2022 | Purdue | 30 | at | Indiana | 16 | |||
| Rutgers | 0 | at | Maryland | 37 | ||||
| Illinois | 41 | at | Northwestern | 3 | ||||
| Michigan | 45 | at | Ohio State | 23 | ||||
| Michigan State | 16 | at | Penn State | 35 | ||||
| Minnesota | 23 | at | Wisconsin | 16 | ||||
| 12/3/2022 | Purdue | 22 | vs | Michigan | 43 | B10 Championship Indianapolis IN | ||
| 12/27/2022 | Wisconsin | 24 | vs | Oklahoma State | 17 | Phoenix AZ | vs B12 | |
| 12/29/2022 | Syracuse | 20 | vs | Minnesota | 28 | Bronx NY | vs ACC | |
| 12/30/2022 | Maryland | 16 | vs | North Carolina State | 12 | Charlotte NC | vs ACC | |
| 12/31/2022 | Ohio State | 41 | vs | Georgia | 42 | Atlanta GA - FBS semifinal | vs SEC | |
| Iowa | 21 | vs | Kentucky | 0 | Nashville TN | vs SEC | ||
| TCU | 51 | vs | Michigan | 45 | Glendale AZ - FBS semifinal | vs B12 | ||
| 1/2/2023 | Mississippi State | 19 | vs | Illinois | 10 | Tampa FL | vs SEC | |
| LSU | 63 | vs | Purdue | 7 | Orlando FL | vs SEC | ||
| Penn State | 35 | vs | Utah | 21 | Pasadena CA | vs P12 |