| 9/3/2022 | Buffalo | 10 | at | Maryland (8-5) | 31 | at B10 | ||
| 9/10/2022 | Holy Cross (12-1) | 37 | at | Buffalo | 31 | Pat (1AA) | ||
| 9/17/2022 | Buffalo | 26 | at | Coastal Carolina (9-4) | 38 | at SBC | ||
| 9/24/2022 | Buffalo | 50 | at | Eastern Michigan (9-4,5-3) | 31 | |||
| 10/1/2022 | Miami-Ohio (6-7,4-4) | 20 | at | Buffalo | 24 | |||
| 10/8/2022 | Buffalo | 38 | at | Bowling Green (6-7,5-3) | 7 | |||
| 10/15/2022 | Buffalo | 34 | at | Massachusetts (1-11) | 7 | at Ind | ||
| 10/22/2022 | Toledo (9-5,6-3) | 27 | at | Buffalo | 34 | |||
| 11/1/2022 | Buffalo | 24 | at | Ohio (10-4,7-2) | 45 | |||
| 11/9/2022 | Buffalo | 27 | at | Central Michigan (4-8,3-5) | 31 | |||
| 11/19/2022 | Akron (2-10,1-7) | at | Buffalo | PPD | ||||
| 11/26/2022 | Kent State (5-7,4-4) | 30 | at | Buffalo | 27 | OT | ||
| 12/2/2022 | Akron (2-10,1-7) | 22 | at | Buffalo | 23 | |||
| 12/27/2022 | Georgia Southern (6-7) | 21 | vs | Buffalo | 23 | Montgomery AL | SBC |
| vs Buffalo | vs Other Opponents | Buffalo compared to OOs | |
| Record: | 6-7 | 83-82 | |
| Points Scored: | 26.69 | 27.01 | 0.32 |
| Points Allowed: | 28.54 | 28.68 | -0.14 |
| Margin: | -1.85 | -1.67 | 0.18 |
| Total Points: | 55.23 | 55.69 | -0.46 |