| 9/3/2022 | Wofford (3-8,3-5) | 0 | at | Chattanooga | 31 | |||
| 9/10/2022 | Chattanooga | 38 | at | Eastern Illinois (2-9) | 20 | at OVC | ||
| 9/17/2022 | North Alabama (1-10) | 14 | at | Chattanooga | 41 | ASUN | ||
| 9/22/2022 | Chattanooga | 0 | at | Illinois (8-5) | 31 | at B10 | ||
| 10/1/2022 | Chattanooga | 24 | at | East Tennessee St (3-8,1-7) | 16 | |||
| 10/15/2022 | VMI (1-10,0-8) | 13 | at | Chattanooga | 41 | |||
| 10/22/2022 | Mercer (7-4,5-3) | 21 | at | Chattanooga | 41 | |||
| 10/29/2022 | Chattanooga | 20 | at | Furman (10-3,7-1) | 24 | |||
| 11/5/2022 | Chattanooga | 31 | at | The Citadel (4-7,3-5) | 21 | |||
| 11/12/2022 | Samford (11-2,8-0) | 35 | at | Chattanooga | 24 | |||
| 11/19/2022 | Chattanooga | 29 | at | Western Carolina (6-5,4-4) | 32 |
| vs Chattanooga | vs Other Opponents | Chattanooga compared to OOs | |
| Record: | 4-7 | 52-64 | |
| Points Scored: | 20.64 | 27.59 | 6.95 |
| Points Allowed: | 29.09 | 27.54 | 1.55 |
| Margin: | -8.45 | 0.05 | 8.50 |
| Total Points: | 49.73 | 55.13 | -5.40 |