| 9/3/2022 | Grambling (3-8) | 3 | at | Arkansas State | 58 | SWAC (1AA) | ||
| 9/10/2022 | Arkansas State | 12 | at | Ohio State (11-2) | 45 | at B10 | ||
| 9/17/2022 | Arkansas State | 32 | at | Memphis (7-6) | 44 | at AAC | ||
| 9/24/2022 | Arkansas State | 26 | at | Old Dominion (3-9,2-6) | 29 | |||
| 10/1/2022 | UL Monroe (4-8,3-5) | 28 | at | Arkansas State | 45 | |||
| 10/8/2022 | James Madison (8-3,6-2) | 42 | at | Arkansas State | 20 | |||
| 10/15/2022 | Arkansas State | 19 | at | Southern Miss (7-6,4-4) | 20 | |||
| 10/22/2022 | Arkansas State | 18 | at | UL Lafayette (6-7,4-4) | 38 | |||
| 10/29/2022 | South Alabama (10-3,7-1) | 31 | at | Arkansas State | 3 | |||
| 11/12/2022 | Massachusetts (1-11) | 33 | at | Arkansas State | 35 | Ind | ||
| 11/19/2022 | Arkansas State | 13 | at | Texas State (4-8,2-6) | 16 | |||
| 11/26/2022 | Troy (12-2,8-1) | 48 | at | Arkansas State | 19 |
| vs Arkansas State | vs Other Opponents | Arkansas State compared to OOs | |
| Record: | 9-3 | 67-70 | |
| Points Scored: | 31.42 | 26.65 | -4.77 |
| Points Allowed: | 25.00 | 25.15 | -0.15 |
| Margin: | 6.42 | 1.50 | -4.92 |
| Total Points: | 56.42 | 51.80 | 4.62 |