| 9/1/2022 | Western Illinois | 25 | at | Tennessee-Martin (7-4) | 42 | at OVC | ||
| 9/10/2022 | Western Illinois | 10 | at | Minnesota (9-4) | 62 | at B10 | ||
| 9/17/2022 | Southern Utah (5-6) | 17 | at | Western Illinois | 10 | WAC | ||
| 9/24/2022 | Northern Iowa (6-5,5-3) | 52 | at | Western Illinois | 17 | |||
| 10/1/2022 | Western Illinois | 10 | at | South Dakota State (14-1,9-0) | 34 | |||
| 10/15/2022 | Western Illinois | 7 | at | Southern Illinois (5-6,4-4) | 30 | |||
| 10/22/2022 | Youngstown State (7-4,5-3) | 28 | at | Western Illinois | 27 | |||
| 10/29/2022 | Western Illinois | 14 | at | Missouri State (5-6,3-5) | 64 | |||
| 11/5/2022 | North Dakota State (12-3,7-2) | 56 | at | Western Illinois | 17 | |||
| 11/12/2022 | Indiana State (2-9,1-7) | 21 | at | Western Illinois | 0 | |||
| 11/19/2022 | Western Illinois | 13 | at | Illinois State (6-5,4-4) | 20 | OT |
| vs Western Illinois | vs Other Opponents | Western Illinois compared to OOs | |
| Record: | 11-0 | 67-53 | |
| Points Scored: | 38.73 | 27.81 | -10.92 |
| Points Allowed: | 13.64 | 24.57 | -10.93 |
| Margin: | 25.09 | 3.24 | -21.85 |
| Total Points: | 52.37 | 52.38 | -0.01 |