| 9/3/2022 | Morgan State (4-7) | 7 | at | Georgia Southern | 59 | MEAC (1AA) | ||
| 9/10/2022 | Georgia Southern | 45 | at | Nebraska (4-8) | 42 | at B10 | ||
| 9/17/2022 | Georgia Southern | 21 | at | UAB (7-6) | 35 | at CUSA | ||
| 9/24/2022 | Ball State (5-7) | 23 | at | Georgia Southern | 34 | MAC | ||
| 10/1/2022 | Georgia Southern | 30 | at | Coastal Carolina (9-4,6-3) | 34 | |||
| 10/8/2022 | Georgia Southern | 33 | at | Georgia State (4-8,3-5) | 41 | |||
| 10/15/2022 | James Madison (8-3,6-2) | 38 | at | Georgia Southern | 45 | |||
| 10/22/2022 | Georgia Southern | 28 | at | Old Dominion (3-9,2-6) | 23 | |||
| 11/5/2022 | South Alabama (10-3,7-1) | 38 | at | Georgia Southern | 31 | |||
| 11/10/2022 | Georgia Southern | 17 | at | UL Lafayette (6-7,4-4) | 36 | |||
| 11/19/2022 | Marshall (9-4,5-3) | 23 | at | Georgia Southern | 10 | |||
| 11/26/2022 | Appalachian State (6-6,3-5) | 48 | at | Georgia Southern | 51 | 2OT | ||
| 12/27/2022 | Georgia Southern | 21 | vs | Buffalo (7-6) | 23 | Montgomery AL | vs MAC |
| vs Georgia Southern | vs Other Opponents | Georgia Southern compared to OOs | |
| Record: | 7-6 | 75-72 | |
| Points Scored: | 31.62 | 27.30 | -4.32 |
| Points Allowed: | 32.69 | 24.66 | 8.03 |
| Margin: | -1.07 | 2.64 | 3.71 |
| Total Points: | 64.31 | 51.96 | 12.35 |