| 9/1/2022 | Central Michigan (4-8) | 44 | at | Oklahoma State | 58 | MAC | ||
| 9/10/2022 | Arizona State (3-9) | 17 | at | Oklahoma State | 34 | P12 | ||
| 9/17/2022 | Ark Pine Bluff (3-8) | 7 | at | Oklahoma State | 63 | SWAC (1AA) | ||
| 10/1/2022 | Oklahoma State | 36 | at | Baylor (6-7,4-5) | 25 | |||
| 10/8/2022 | Texas Tech (8-5,5-4) | 31 | at | Oklahoma State | 41 | |||
| 10/15/2022 | Oklahoma State | 40 | at | TCU (13-2,9-1) | 43 | 2OT | ||
| 10/22/2022 | Texas (8-5,6-3) | 34 | at | Oklahoma State | 41 | |||
| 10/29/2022 | Oklahoma State | 0 | at | Kansas State (10-4,8-2) | 48 | |||
| 11/5/2022 | Oklahoma State | 16 | at | Kansas (6-7,3-6) | 37 | |||
| 11/12/2022 | Iowa State (4-8,1-8) | 14 | at | Oklahoma State | 20 | |||
| 11/19/2022 | Oklahoma State | 13 | at | Oklahoma (6-7,3-6) | 28 | |||
| 11/26/2022 | West Virginia (5-7,3-6) | 24 | at | Oklahoma State | 19 | |||
| 12/27/2022 | Wisconsin (7-6) | 24 | vs | Oklahoma State | 17 | Phoenix AZ | B10 |
| vs Oklahoma State | vs Other Opponents | Oklahoma State compared to OOs | |
| Record: | 6-7 | 77-76 | |
| Points Scored: | 28.92 | 30.60 | 1.68 |
| Points Allowed: | 30.62 | 27.54 | 3.08 |
| Margin: | -1.70 | 3.06 | 4.76 |
| Total Points: | 59.54 | 58.14 | 1.40 |