| 9/3/2022 | Florida Atlantic (5-7) | 38 | at | Ohio | 41 | CUSA | ||
| 9/10/2022 | Ohio | 10 | at | Penn State (11-2) | 46 | at B10 | ||
| 9/17/2022 | Ohio | 10 | at | Iowa State (4-8) | 43 | at B12 | ||
| 9/24/2022 | Fordham (9-3) | 52 | at | Ohio | 59 | Pat (1AA) | ||
| 10/1/2022 | Ohio | 24 | at | Kent State (5-7,4-4) | 31 | OT | ||
| 10/8/2022 | Akron (2-10,1-7) | 34 | at | Ohio | 55 | |||
| 10/15/2022 | Ohio | 33 | at | Western Michigan (5-7,4-4) | 14 | |||
| 10/22/2022 | Northern Illinois (3-9,2-6) | 17 | at | Ohio | 24 | |||
| 11/1/2022 | Buffalo (7-6,5-3) | 24 | at | Ohio | 45 | |||
| 11/8/2022 | Ohio | 37 | at | Miami-Ohio (6-7,4-4) | 21 | |||
| 11/15/2022 | Ohio | 32 | at | Ball State (5-7,3-5) | 18 | |||
| 11/22/2022 | Bowling Green (6-7,5-3) | 14 | at | Ohio | 38 | |||
| 12/3/2022 | Toledo (9-5,6-3) | 17 | vs | Ohio | 7 | MAC ChampionshipDetroit MI | ||
| 12/30/2022 | Ohio | 30 | vs | Wyoming (7-6) | 27 | OT | Tucson AZ | vs MW |
| vs Ohio | vs Other Opponents | Ohio compared to OOs | |
| Record: | 4-10 | 80-81 | |
| Points Scored: | 28.29 | 27.02 | -1.27 |
| Points Allowed: | 31.79 | 26.52 | 5.27 |
| Margin: | -3.50 | 0.50 | 4.00 |
| Total Points: | 60.08 | 53.54 | 6.54 |