| 9/1/2022 | LIU (4-7) | 0 | at | Toledo | 37 | NE (1AA) | ||
| 9/10/2022 | Massachusetts (1-11) | 10 | at | Toledo | 55 | Ind | ||
| 9/17/2022 | Toledo | 21 | at | Ohio State (11-2) | 77 | at B10 | ||
| 9/24/2022 | Toledo | 14 | at | San Diego State (7-6) | 17 | at MW | ||
| 10/1/2022 | Central Michigan (4-8,3-5) | 17 | at | Toledo | 38 | |||
| 10/8/2022 | Toledo | 52 | at | Northern Illinois (3-9,2-6) | 32 | |||
| 10/15/2022 | Kent State (5-7,4-4) | 31 | at | Toledo | 52 | |||
| 10/22/2022 | Toledo | 27 | at | Buffalo (7-6,5-3) | 34 | |||
| 10/29/2022 | Toledo | 27 | at | Eastern Michigan (9-4,5-3) | 24 | |||
| 11/8/2022 | Ball State (5-7,3-5) | 21 | at | Toledo | 28 | |||
| 11/15/2022 | Bowling Green (6-7,5-3) | 42 | at | Toledo | 35 | |||
| 11/25/2022 | Toledo | 14 | at | Western Michigan (5-7,4-4) | 20 | |||
| 12/3/2022 | Toledo | 17 | vs | Ohio (10-4,7-2) | 7 | MAC ChampionshipDetroit MI | ||
| 12/20/2022 | Liberty (8-5) | 19 | vs | Toledo | 21 | Boca Raton FL | Ind |
| vs Toledo | vs Other Opponents | Toledo compared to OOs | |
| Record: | 5-9 | 80-81 | |
| Points Scored: | 25.07 | 26.44 | 1.37 |
| Points Allowed: | 31.29 | 27.57 | 3.72 |
| Margin: | -6.22 | -1.13 | 5.09 |
| Total Points: | 56.36 | 54.01 | 2.35 |