| 9/1/2022 | North Alabama (1-10) | 14 | at | Indiana State | 17 | OT | ASUN | |
| 9/10/2022 | Indiana State | 0 | at | Purdue (8-6) | 56 | at B10 | ||
| 9/17/2022 | Montana (8-5) | 49 | at | Indiana State | 14 | BSky | ||
| 10/1/2022 | Indiana State | 14 | at | Northern Iowa (6-5,5-3) | 20 | |||
| 10/8/2022 | North Dakota State (12-3,7-2) | 31 | at | Indiana State | 26 | |||
| 10/15/2022 | Indiana State | 42 | at | Youngstown State (7-4,5-3) | 48 | |||
| 10/22/2022 | Illinois State (6-5,4-4) | 27 | at | Indiana State | 21 | |||
| 10/29/2022 | Indiana State | 7 | at | South Dakota State (14-1,9-0) | 49 | |||
| 11/5/2022 | North Dakota (7-5,5-3) | 42 | at | Indiana State | 7 | |||
| 11/12/2022 | Indiana State | 21 | at | Western Illinois (0-11,0-8) | 0 | |||
| 11/19/2022 | Missouri State (5-6,3-5) | 24 | at | Indiana State | 7 |
| vs Indiana State | vs Other Opponents | Indiana State compared to OOs | |
| Record: | 9-2 | 65-59 | |
| Points Scored: | 32.73 | 28.27 | -4.46 |
| Points Allowed: | 16.00 | 27.12 | -11.12 |
| Margin: | 16.73 | 1.15 | -15.58 |
| Total Points: | 48.73 | 55.39 | -6.66 |