| 9/1/2022 | St Francis PA (9-3) | 23 | at | Akron | 30 | OT | NE (1AA) | |
| 9/10/2022 | Akron | 0 | at | Michigan State (5-7) | 52 | at B10 | ||
| 9/17/2022 | Akron | 6 | at | Tennessee (11-2) | 63 | at SEC | ||
| 9/24/2022 | Akron | 12 | at | Liberty (8-5) | 21 | at Ind | ||
| 10/1/2022 | Bowling Green (6-7,5-3) | 31 | at | Akron | 28 | |||
| 10/8/2022 | Akron | 34 | at | Ohio (10-4,7-2) | 55 | |||
| 10/15/2022 | Central Michigan (4-8,3-5) | 28 | at | Akron | 21 | |||
| 10/22/2022 | Akron | 27 | at | Kent State (5-7,4-4) | 33 | |||
| 10/29/2022 | Miami-Ohio (6-7,4-4) | 27 | at | Akron | 9 | |||
| 11/8/2022 | Eastern Michigan (9-4,5-3) | 34 | at | Akron | 28 | |||
| 11/19/2022 | Akron | at | Buffalo (7-6,5-3) | PPD | ||||
| 11/26/2022 | Akron | 44 | at | Northern Illinois (3-9,2-6) | 12 | |||
| 12/2/2022 | Akron | 22 | at | Buffalo (7-6,5-3) | 23 |
| vs Akron | vs Other Opponents | Akron compared to OOs | |
| Record: | 10-2 | 79-73 | |
| Points Scored: | 33.50 | 28.86 | -4.64 |
| Points Allowed: | 21.75 | 27.62 | -5.87 |
| Margin: | 11.75 | 1.24 | -10.51 |
| Total Points: | 55.25 | 56.48 | -1.23 |