| 9/2/2022 | Western Michigan | 13 | at | Michigan State (5-7) | 35 | at B10 | ||
| 9/10/2022 | Western Michigan | 37 | at | Ball State (5-7,3-5) | 30 | |||
| 9/17/2022 | Pittsburgh (9-4) | 34 | at | Western Michigan | 13 | ACC | ||
| 9/24/2022 | Western Michigan | 6 | at | San Jose State (7-5) | 34 | at MW | ||
| 10/1/2022 | New Hampshire (9-4) | 7 | at | Western Michigan | 44 | CAAF (1AA) | ||
| 10/8/2022 | Eastern Michigan (9-4,5-3) | 45 | at | Western Michigan | 23 | |||
| 10/15/2022 | Ohio (10-4,7-2) | 33 | at | Western Michigan | 14 | |||
| 10/22/2022 | Western Michigan | 16 | at | Miami-Ohio (6-7,4-4) | 10 | |||
| 11/2/2022 | Western Michigan | 9 | at | Bowling Green (6-7,5-3) | 13 | |||
| 11/9/2022 | Northern Illinois (3-9,2-6) | 24 | at | Western Michigan | 21 | |||
| 11/16/2022 | Western Michigan | 12 | at | Central Michigan (4-8,3-5) | 10 | |||
| 11/25/2022 | Toledo (9-5,6-3) | 14 | at | Western Michigan | 20 |
| vs Western Michigan | vs Other Opponents | Western Michigan compared to OOs | |
| Record: | 7-5 | 75-66 | |
| Points Scored: | 24.08 | 27.43 | 3.35 |
| Points Allowed: | 19.00 | 27.93 | -8.93 |
| Margin: | 5.08 | -0.50 | -5.58 |
| Total Points: | 43.08 | 55.36 | -12.28 |