| 9/3/2022 | Louisville (8-5,4-4) | 7 | at | Syracuse | 31 | |||
| 9/10/2022 | Syracuse | 48 | at | Connecticut (6-7) | 14 | at Ind | ||
| 9/17/2022 | Purdue (8-6) | 29 | at | Syracuse | 32 | B10 | ||
| 9/23/2022 | Virginia (3-7,1-6) | 20 | at | Syracuse | 22 | |||
| 10/1/2022 | Wagner (1-10) | 0 | at | Syracuse | 59 | NE (1AA) | ||
| 10/15/2022 | North Carolina State (8-5,4-4) | 9 | at | Syracuse | 24 | |||
| 10/22/2022 | Syracuse | 21 | at | Clemson (11-3,9-0) | 27 | |||
| 10/29/2022 | Notre Dame (9-4) | 41 | at | Syracuse | 24 | ND | ||
| 11/5/2022 | Syracuse | 9 | at | Pittsburgh (9-4,5-3) | 19 | |||
| 11/12/2022 | Florida State (10-3,5-3) | 38 | at | Syracuse | 3 | |||
| 11/19/2022 | Syracuse | 35 | at | Wake Forest (8-5,3-5) | 45 | |||
| 11/26/2022 | Syracuse | 32 | at | Boston College (3-9,2-6) | 23 | |||
| 12/29/2022 | Syracuse | 20 | vs | Minnesota (9-4) | 28 | Bronx NY | vs B10 |
| vs Syracuse | vs Other Opponents | Syracuse compared to OOs | |
| Record: | 6-7 | 87-65 | |
| Points Scored: | 23.08 | 27.07 | 3.99 |
| Points Allowed: | 27.69 | 24.03 | 3.66 |
| Margin: | -4.61 | 3.04 | 7.65 |
| Total Points: | 50.77 | 51.10 | -0.33 |