| 9/3/2022 | UTEP (5-7) | 13 | at | Oklahoma | 45 | CUSA | ||
| 9/10/2022 | Kent State (5-7) | 3 | at | Oklahoma | 33 | MAC | ||
| 9/17/2022 | Oklahoma | 49 | at | Nebraska (4-8) | 14 | at B10 | ||
| 9/24/2022 | Kansas State (10-4,8-2) | 41 | at | Oklahoma | 34 | |||
| 10/1/2022 | Oklahoma | 24 | at | TCU (13-2,9-1) | 55 | |||
| 10/8/2022 | Texas (8-5,6-3) | 49 | vs | Oklahoma | 0 | Dallas TX | ||
| 10/15/2022 | Kansas (6-7,3-6) | 42 | at | Oklahoma | 52 | |||
| 10/29/2022 | Oklahoma | 27 | at | Iowa State (4-8,1-8) | 13 | |||
| 11/5/2022 | Baylor (6-7,4-5) | 38 | at | Oklahoma | 35 | |||
| 11/12/2022 | Oklahoma | 20 | at | West Virginia (5-7,3-6) | 23 | |||
| 11/19/2022 | Oklahoma State (7-6,4-5) | 13 | at | Oklahoma | 28 | |||
| 11/26/2022 | Oklahoma | 48 | at | Texas Tech (8-5,5-4) | 51 | OT | ||
| 12/29/2022 | Oklahoma | 32 | vs | Florida State (10-3) | 35 | Orlando FL | vs ACC |
| vs Oklahoma | vs Other Opponents | Oklahoma compared to OOs | |
| Record: | 7-6 | 84-70 | |
| Points Scored: | 30.00 | 31.16 | 1.16 |
| Points Allowed: | 32.85 | 26.42 | 6.43 |
| Margin: | -2.85 | 4.74 | 7.59 |
| Total Points: | 62.85 | 57.58 | 5.27 |