| 9/3/2022 | Cincinnati | 24 | at | Arkansas (7-6) | 31 | at SEC | ||
| 9/10/2022 | Kennesaw St (5-6) | 10 | at | Cincinnati | 63 | ASUN (1AA) | ||
| 9/17/2022 | Cincinnati | 38 | at | Miami-Ohio (6-7) | 17 | at MAC | ||
| 9/24/2022 | Indiana (4-8) | 24 | at | Cincinnati | 45 | B10 | ||
| 10/1/2022 | Cincinnati | 31 | at | Tulsa (5-7,3-5) | 21 | |||
| 10/8/2022 | South Florida (1-11,0-8) | 24 | at | Cincinnati | 28 | |||
| 10/22/2022 | Cincinnati | 29 | at | SMU (7-6,5-3) | 27 | |||
| 10/29/2022 | Cincinnati | 21 | at | UCF (9-5,6-3) | 25 | |||
| 11/5/2022 | Navy (4-8,4-4) | 10 | at | Cincinnati | 20 | |||
| 11/11/2022 | East Carolina (8-5,4-4) | 25 | at | Cincinnati | 27 | |||
| 11/19/2022 | Cincinnati | 23 | at | Temple (3-9,1-7) | 3 | |||
| 11/25/2022 | Tulane (12-2,8-1) | 27 | at | Cincinnati | 24 | |||
| 12/17/2022 | Cincinnati | 7 | vs | Louisville (8-5) | 24 | Boston MA | vs ACC |
| vs Cincinnati | vs Other Opponents | Cincinnati compared to OOs | |
| Record: | 4-9 | 75-76 | |
| Points Scored: | 20.62 | 29.46 | 8.84 |
| Points Allowed: | 29.23 | 28.62 | 0.61 |
| Margin: | -8.61 | 0.84 | 9.45 |
| Total Points: | 49.85 | 58.08 | -8.23 |