| 9/3/2022 | Memphis (7-6) | 23 | at | Mississippi State | 49 | AAC | ||
| 9/10/2022 | Mississippi State | 39 | at | Arizona (5-7) | 17 | at P12 | ||
| 9/17/2022 | Mississippi State | 16 | at | LSU (10-4,6-3) | 31 | |||
| 9/24/2022 | Bowling Green (6-7) | 14 | at | Mississippi State | 45 | MAC | ||
| 10/1/2022 | Texas A&M (5-7,2-6) | 24 | at | Mississippi State | 42 | |||
| 10/8/2022 | Arkansas (7-6,3-5) | 17 | at | Mississippi State | 40 | |||
| 10/15/2022 | Mississippi State | 17 | at | Kentucky (7-6,3-5) | 27 | |||
| 10/22/2022 | Mississippi State | 6 | at | Alabama (11-2,6-2) | 30 | |||
| 11/5/2022 | Auburn (5-7,2-6) | 33 | at | Mississippi State | 39 | OT | ||
| 11/12/2022 | Georgia (15-0,9-0) | 45 | at | Mississippi State | 19 | |||
| 11/19/2022 | East Tennessee St (3-8) | 7 | at | Mississippi State | 56 | SoCon (1AA) | ||
| 11/24/2022 | Mississippi State | 24 | at | Mississippi (8-5,4-4) | 22 | |||
| 1/2/2023 | Mississippi State | 19 | vs | Illinois (8-5) | 10 | Tampa FL | vs B10 |
| vs Mississippi State | vs Other Opponents | Mississippi State compared to OOs | |
| Record: | 4-9 | 93-61 | |
| Points Scored: | 23.08 | 31.16 | 8.08 |
| Points Allowed: | 31.62 | 23.66 | 7.96 |
| Margin: | -8.54 | 7.50 | 16.04 |
| Total Points: | 54.70 | 54.82 | -0.12 |