| 9/3/2022 | Illinois State | 0 | at | Wisconsin (7-6) | 38 | at B10 | ||
| 9/10/2022 | Valparaiso (5-7) | 21 | at | Illinois State | 28 | Pio | ||
| 9/17/2022 | Eastern Illinois (2-9) | 7 | at | Illinois State | 35 | OVC | ||
| 10/1/2022 | Southern Illinois (5-6,4-4) | 19 | at | Illinois State | 14 | |||
| 10/8/2022 | Illinois State | 23 | at | Northern Iowa (6-5,5-3) | 21 | |||
| 10/15/2022 | South Dakota (3-8,2-6) | 10 | at | Illinois State | 12 | |||
| 10/22/2022 | Illinois State | 27 | at | Indiana State (2-9,1-7) | 21 | |||
| 10/29/2022 | Illinois State | 7 | at | North Dakota State (12-3,7-2) | 24 | |||
| 11/5/2022 | Youngstown State (7-4,5-3) | 19 | at | Illinois State | 17 | |||
| 11/12/2022 | Illinois State | 7 | at | South Dakota State (14-1,9-0) | 31 | |||
| 11/19/2022 | Western Illinois (0-11,0-8) | 13 | at | Illinois State | 20 | OT |
| vs Illinois State | vs Other Opponents | Illinois State compared to OOs | |
| Record: | 5-6 | 58-63 | |
| Points Scored: | 20.36 | 26.04 | 5.68 |
| Points Allowed: | 17.27 | 27.11 | -9.84 |
| Margin: | 3.09 | -1.07 | -4.16 |
| Total Points: | 37.63 | 53.15 | -15.52 |