| 8/27/2022 | Wyoming | 6 | at | Illinois (8-5) | 38 | at B10 | ||
| 9/3/2022 | Tulsa (5-7) | 37 | at | Wyoming | 40 | 2OT | AAC | |
| 9/10/2022 | Northern Colorado (3-8) | 10 | at | Wyoming | 33 | BSky (1AA) | ||
| 9/16/2022 | Air Force (10-3,5-3) | 14 | at | Wyoming | 17 | |||
| 9/24/2022 | Wyoming | 24 | at | BYU (8-5) | 38 | at Ind | ||
| 10/1/2022 | San Jose State (7-5,5-3) | 33 | at | Wyoming | 16 | |||
| 10/8/2022 | Wyoming | 27 | at | New Mexico (2-10,0-8) | 14 | |||
| 10/22/2022 | Utah State (6-7,5-3) | 14 | at | Wyoming | 28 | |||
| 10/29/2022 | Wyoming | 27 | at | Hawaii (3-10,2-6) | 20 | |||
| 11/12/2022 | Wyoming | 14 | at | Colorado State (3-9,3-5) | 13 | |||
| 11/19/2022 | Boise State (10-4,8-1) | 20 | at | Wyoming | 17 | |||
| 11/25/2022 | Wyoming | 0 | at | Fresno State (10-4,8-1) | 30 | |||
| 12/30/2022 | Ohio (10-4) | 30 | vs | Wyoming | 27 | OT | Tucson AZ | MAC |
| vs Wyoming | vs Other Opponents | Wyoming compared to OOs | |
| Record: | 6-7 | 79-74 | |
| Points Scored: | 23.92 | 25.13 | 1.21 |
| Points Allowed: | 21.23 | 25.83 | -4.60 |
| Margin: | 2.69 | -0.70 | -3.39 |
| Total Points: | 45.15 | 50.96 | -5.81 |