| 9/3/2022 | Miami-Ohio (6-7) | 13 | at | Kentucky | 37 | MAC | ||
| 9/10/2022 | Kentucky | 26 | at | Florida (6-7,3-5) | 16 | |||
| 9/17/2022 | Youngstown State (7-4) | 0 | at | Kentucky | 31 | MVC (1AA) | ||
| 9/24/2022 | Northern Illinois (3-9) | 23 | at | Kentucky | 31 | MAC | ||
| 10/1/2022 | Kentucky | 19 | at | Mississippi (8-5,4-4) | 22 | |||
| 10/8/2022 | South Carolina (8-5,4-4) | 24 | at | Kentucky | 14 | |||
| 10/15/2022 | Mississippi State (9-4,4-4) | 17 | at | Kentucky | 27 | |||
| 10/29/2022 | Kentucky | 6 | at | Tennessee (11-2,6-2) | 44 | |||
| 11/5/2022 | Kentucky | 21 | at | Missouri (6-7,3-5) | 17 | |||
| 11/12/2022 | Vanderbilt (5-7,2-6) | 24 | at | Kentucky | 21 | |||
| 11/19/2022 | Georgia (15-0,9-0) | 16 | at | Kentucky | 6 | |||
| 11/26/2022 | Louisville (8-5) | 13 | at | Kentucky | 26 | ACC | ||
| 12/31/2022 | Iowa (8-5) | 21 | vs | Kentucky | 0 | Nashville TN | B10 |
| vs Kentucky | vs Other Opponents | Kentucky compared to OOs | |
| Record: | 6-7 | 94-60 | |
| Points Scored: | 19.23 | 30.62 | 11.39 |
| Points Allowed: | 20.38 | 24.51 | -4.13 |
| Margin: | -1.15 | 6.11 | 7.26 |
| Total Points: | 39.61 | 55.13 | -15.52 |